1. Upper dyspepsia that is not amenable to appropriate therapy
2. Upper dyspepsia at the age of more than 50 years
3.Dysphagia
4. Odinophagy
5.Anorexia
6. Reflux symptoms that are not amenable to appropriate therapy
7. Persistent vomiting
8. Special cases: after long term anticoagulant therapy, NSAIDs
9. Family adenomatous polyposis
10. Radiological findings: neoplasia, strictures, obstruction
11. Gastrointestinal bleeding
12. Iron deficiency anemia
13. The need for a biopsy
14. Portal hypertension
15. Examination of mucosa after chemical burns
16. Control and treatment of bleeding lesion: vascular pathology, ulcer, tumor
17. Varicose vein ligation or sclerotherapy
18. Removal of the foreign body
19. Removal of polyps
20. Oral nutrition (probe, PEG)
21. Dilation of stenoses
22. Cardiac achalasia treatment
23. Intestinal metaplasia treatment